The present study aimed to provide a cultural development model aligned with the Fourth Industrial Revolution. The research was applied in terms of its purpose, cross-sectional regarding time, and of a mixed-methods nature (sequential exploratory) conducted in two qualitative and quantitative phases. The qualitative phase was a meta-synthesis, while the quantitative phase was descriptive-correlational. The statistical population in the qualitative phase included document analysis and experts from public organizations in Iran as well as academic scholars. The sample size was determined to be 20 individuals in the qualitative phase, based on the principle of saturation, and 335 individuals in the quantitative phase, using sample size calculations for structural equation modeling. Sampling was purposive in the qualitative phase and non-random quota sampling in the quantitative phase. In the qualitative phase, data collection utilized two methods: (a) meta-synthesis (research synthesis) based on a systematic review and (b) semi-structured interviews. Reliability in this phase was ensured through intracoder reliability, and content validity was assessed. In the quantitative phase, descriptive and inferential statistical analyses were applied. Tests such as one-sample t-tests and structural equation modeling using SPSS and SmartPLS software were employed. Additionally, fuzzy AHP was used to prioritize the components. The results indicated that cultural development aligned with the Fourth Industrial Revolution includes six components: organizational structure, strategic thinking, innovation, individuals, leadership, and technical systems. Among these components, technical systems were identified as the top priority.