The present study aims to design a human resource development model in the hospitals of Lorestan Province. The research method is descriptive-survey. In terms of data type, the study adopts a mixed-methods approach. Qualitative and quantitative data were collected through library and field research. The statistical population consisted of 18 experts and academic specialists, who were selected using the snowball sampling method based on the principle of theoretical saturation. The research tool was semi-structured interviews, whose validity and reliability were confirmed. Qualitative data analysis was conducted using content analysis and coding through MAXQDA software, while quantitative data analysis was performed using interpretive structural modeling and MATLAB software. The research findings were presented in the form of a human resource development model for hospitals in Lorestan Province, structured into five levels. The executive recommendations for the hospital staff development system include redesigning internship processes in response to evolving needs and rapid technological changes, restructuring assessment and learning mechanisms to institutionalize an evaluation culture, redesigning the performance evaluation system, salary and reward systems, enhancing organizational commitment, and establishing processes to align individual and organizational goals.