This study was conducted to identify the academic challenges faced by students in gifted and talented schools (SAMPAD). The research employs a qualitative methodology using Barroso and Sandelowski's seven-step meta-synthesis approach. Researchers systematically reviewed relevant studies in academic databases including SID, Noormags, Magiran, the Comprehensive Portal of Humanities, Civilica, and Elmnet between 2016-2024. From 184 initial sources, 20 studies were selected for thematic analysis. The reliability of indicators, measured by Cohen's Kappa coefficient in SPSS 26, was calculated at 0.813. Content analysis of the selected sources yielded 196 initial codes, categorized into 32 sub-themes and further grouped into seven main themes: Individual Challenges (cognitive challenges, academic struggles, communication and interaction difficulties, personal expectations) , Family Challenges (parents' occupational issues, family attitudes, family culture, family dynamics, parental expectations) , School-Level Challenges (poor management style, teacher inefficiency, inadequate school planning, weak educational facilities, school infrastructure, financial constraints, SAMPAD policies) , Educational Challenges (curriculum, instructional content, teaching-learning methods, instructional time, assessment and evaluation) , Environmental Challenges (political, social, economic, cultural, legal factors, weak family-school connection, migration) , Technological and IT Deficiencies (lack of technological equipment, virtual networks) , Employment Crisis (job opportunities, career attitudes). The findings indicate that improving SAMPAD schools requires comprehensive reforms. Without such structural changes, a decline in education quality and the burnout of gifted students appears inevitable.